Endocrine Abstracts

Objective: The tumor suppressor gene methylation lead to gene silencing, it plays an important role in thyroid tumor occurrence and development. This study examined the tumor suppressor gene (PTEN, RASSF1A, DAPK, RARβ2) DNA methylation and mRNA expression status in the peripheral blood of patients with nodular thyroid disease. Discuss its clinical significance. For the benign and malignant thyroid nodules early identification of molecular diagnosis is based.<p class="...

Introduction: Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe drug eruption with systemic involvement. Visceral manifestations consisting of fulminant hepatic failure, myocarditis, interstitial nephritis, pneumonitis and autoimmune hypothyroidism are known sequela. We report a case of DRESS syndrome post Bactrim (sulfamethoxazole and trimethoprim) therapy complicated by both myocarditis and autoimmune thyrotoxicosis.Case report: A p...

Introduction: Panhypopituitarism is a known but rare presentation of lymphoproliferative disease. We describe a patient with newly diagnosed advanced diffuse large B-cell lymphoma who presented with anterior hypopituitarism and concomitant adrenal gland involvement.Case report: A 72 year-old Chinese woman presented with a few weeks’ duration of lethargy, weight loss and functional decline. A hormonal screen done at admission suggested central hypoth...

Introduction: Hypogonadism is known to persist after treatment of hyperprolactinemia, necessitating androgen therapy in young male patients. Aromatisation of testosterone to estradiol can result in tumor expansion. We report a patient with persistent hypogonadism post treatment of macroprolactinoma and discuss challenges involved in the management.Case report: A 51-year-old gentleman was admitted for streptococcal meningitis. Brain imaging revealed a pit...

Introduction: Male hypogonadism secondary to AIDS is common and may present with non specific symptoms. Patients may self-diagnose hypogonadism and seek unauthorised androgen therapy. We report a male patient who developed polycythemia after receiving unauthorised sources of androgen therapy.Case report: A 42 years old man with AIDS diagnosed 10 years ago has repeatedly refused antiretroviral therapy. His most recent CD4 count was 314 cells/μl. His ...

Introduction: Mild hypercalcaemia can present in 10–15% of hyperthyroid patients. In contrast, its incidence in B cell lymphoma is considerably less (7–8%) but its levels are much higher. We report a patient with hypercalcemia secondary to both thyrotoxicosis and lymphoma.Case report: A 55 year-old lady presented with non specific symptoms of appetite loss and lower limb weakness. Comorbidities included hypertension, diabetes mellitus, hyperlip...

Introduction: One of the main challenges in the management of male hypogonadotropic hypogonadism (HH) is in the restoration of fertility. We describe 2 patients with HH and discuss the difficulties involved in their management.Case (1): A 23-year-old Chinese man presented with lack of secondary sexual characteristics. Examination revealed Tanner Stage 2 with descended testes measuring 6 ml bilaterally. Laboratory results: total testosterone (TT) <1 n...